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Reggae A major breakthrough has been reached in the study of what makes brain function, enabling a detailed view of what goes wrong, why, and how to improve it.
Published today in Nature, the work led by Cambridge University researcher Professor David Nutt, could open the
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The study, funded by Medical Research Council, looked at the role of different brain chemicals, and found that a number of them interact with each other to form a complex set of responses in a neural network.
This is in stark contrast with conventional views which have tended to assume that only one substance drives these functions, but in fact some cases one or more substances could be the key.
Nutt's work also shed new light on how the brain is altered by ageing, and it has implications for the development of Parkinson's drugs, which have so far only been approved in the US and France.
The work, conducted by researchers from Cambridge's Department of Neuroscience, the University Edinburgh's Centre for Neuroimaging and Cognitive Neuroscience the University of Oxford, also has implications for memory, a key area in which cognition is impaired Alzheimer's and Parkinson's.
The paper also builds on another study conducted by Professor Nutt, in which he used brain imaging and optogenetics – a breakthrough technique in which electrical signals can be triggered by light to control neurons – show that changes in the activity of individual "neurons" are linked with brain diseases such as Parkinson's.
These findings were then followed up by other research led the UK Medical Council Cambridge Centre for Neuroimaging and Cognitive Neuronal Networks, which aimed to understand the link between brain networks and changes in behavior, order to improve the efficiency of clinical trials and create drugs that may be more effective than drugs currently available.
Professor Nutt said: "The problem with neurodegenerative diseases such as Parkinson's and Alzheimer's is that"
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